. SAM-e increases glutathione, and has not proven to be particularly helpful. . This wont be known for a long time, particularly if nobody is doing careful research on the topic. SAM-e also increases neurotransmitter synthesis, and even when taken with L-tryptophan, does not seem to make much difference. . Also, patients who are considering stopping the drugs must also have informed consent concerning possible difficulties. The citizen scientists of the Internet have labeled the problem protracted withdrawal. . The anxiety and/or depression was not a relapse, because the patients never had these symptoms before starting the drugs. . It had placebo value, but was not an antidote to the problem. Citizen scientists developed a set of corollary beliefs; primarily that the protracted withdrawal is largely due to stopping the drug too fast and that if one waits long enough that the symptoms of protracted withdrawal are going to go away. . In my experience stopping ssris after 5 years of cumulative exposure can be risky, and I am not advising anyone who has taken the drugs for 10 years or more to try to stop unless they are willing to risk disabling symptoms. . The only precedent for this type of presentation is tardive dyskinesia (TD). .
If you know of someone who is thinking about starting or stopping sie sucht ihn sex haute a ssri, please consider sending them a copy of Informed Consent. TD occurs while on antipsychotics, primarily occurs shortly after stopping them, and may occur months or even longer after stopping the drugs. . With the ssris, it is not so much a tardive movement disorder as a tardive problem with akathisia, a sort of constant restlessness or agitation that is accompanied by an agitated anxious/depressed state. . It is the first book that gives warnings for patients who are considering stopping ssris as well as those who are considering starting ssris. . Patients often did well for months, only to develop fairly acute profound states of anxiety and or depression. . To physicians, withdrawal is a phenomenon that starts when the blood level of a substance drops to near zero and persists for a week or two. . If I thought that it was possible, I would have opened a string of clinics all over the country to help get people off of antidepressants. . Shipkos Informed Consent for ssri Antidepressants. . TD is generally associated with antipsychotic medication, and is also a manufacturer labeled side effect of the ssris. . Tapering the drug slowly definitely minimizes the acute symptoms that occur when stopping an ssri but does not appear (imho) to have much bearing on the longer-term and late-onset symptoms that occur when stopping an ssri. . Tardive refers to symptoms that occur later and dyskinesia refers to movement disorder. I expect that the same is true for ssri withdrawal. .
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